Can amendments just wait until the annual review?

Amendments must be reviewed before implementation to ensure the ongoing welfare of the animals involved in research and compliance with ethical standards. This requirement is fundamental to the operation of Institutional Animal Care and Use Committees (IACUCs). Any changes to research protocols can potentially impact animal care, welfare, and the scientific validity of the research. Therefore, these amendments need to be assessed and approved in advance rather than waiting for the annual review, which focuses on the overall program rather than specific protocol changes.

Annual reviews typically encompass a broader evaluation of the institution's entire animal care program, which does not allow for immediate adjustments or oversight of specific protocol changes. This ensures that animal welfare remains a priority and that all research activities are conducted in accordance with institutional policies and regulatory guidelines. Timely review of amendments contributes to both ethical research practices and compliance with regulations.