If a significant deficiency is NOT corrected according to the IACUC semi-annual evaluation report, what is the proper course of action?

In the context of IACUC regulations, when a significant deficiency in animal care or use is identified and remains uncorrected following a semi-annual evaluation, timely reporting is crucial to ensure compliance and uphold animal welfare standards. The correct course of action requires that the situation be reported through the Institutional Official (IO) to the United States Department of Agriculture (USDA) within 15 business days.

This timeline is specified to ensure that the appropriate regulatory authorities are promptly informed of significant deficiencies so they can take necessary actions to address them. A swift response within this timeframe underscores the institution's commitment to resolving issues related to animal care and is a part of maintaining the integrity of the research environment.

The other options suggest longer reporting periods which do not align with the regulatory requirements for addressing significant deficiencies. Reporting outside of the specified 15 business days could lead to prolonged issues regarding animal welfare and compliance, which is why adhering to this timeframe is important.