If an investigator conducts category B, C, and D activities on the same animal, how should that animal be classified?

When assessing the classification of an animal involved in various activities, it is crucial to recognize how the categories are defined and what they entail. In the context of IACUC regulations, activities are categorized from A to E based on the degree of invasiveness and impact these activities may have on the well-being of animals.

Category D includes procedures that are significantly more invasive or stressful than those in the prior categories. If an investigator is conducting activities that fall into categories B, C, and D, it indicates that the most invasive and potentially harmful activities are being performed. The classification should reflect the highest level of animal welfare concern, which in this case is category D due to the nature of the activities being conducted.

Thus, when an animal is subjected to any procedures that meet the criteria for category D, it must be classified as such, regardless of the presence of less invasive activities from categories B and C. This classification helps ensure that proper oversight and ethical considerations are applied, focusing on the most serious implications for the animal's welfare. By adhering to this guideline, institutions maintain compliance with regulatory standards while also prioritizing the ethical treatment of animals in research settings.