In which scenario would the IACUC require a significant review process?

The IACUC requires a significant review process when there is a switch from non-survival to survival surgery. This change represents a substantial alteration in the way animals will be treated in the research protocol. Survival surgery typically involves more rigorous protocols regarding anesthesia, postoperative care, and monitoring of the animals’ overall well-being, as the animals will experience recovery periods following the procedure.

Involving the IACUC in this significant change is essential to ensure that all ethical considerations, animal welfare standards, and regulatory requirements are met. This process allows the committee to evaluate the scientific justification for the change and assess any potential impact it might have on animal health and welfare.

Other options, such as changing the project title or updating the grant information, usually do not necessitate an extensive review since they do not directly affect the care or welfare of the animals. Similarly, revising the personnel list may require some notification but generally does not invoke a significant change in the review process as it pertains to the welfare considerations directly related to the animal subjects involved in the study.