To comply with the law, who must review and sign the IACUC semi-annual self-evaluation report?

The correct answer indicates that a majority of all voting members must review and sign the IACUC semi-annual self-evaluation report before it is submitted to the Chief Executive Officer (CEO). This process ensures that the report is valid and represents the collective assessment of the entire IACUC committee, thereby enhancing the reliability of the findings. The involvement of a majority of voting members also helps to ensure compliance with federal regulations, which require a thorough and comprehensive review to safeguard animal welfare and institutional integrity.

In addition, submitting the signed report to the CEO demonstrates the accountability of the IACUC to the institution's leadership and highlights the importance of oversight in the operation of animal care and use programs. This further emphasizes the governance role that both the IACUC and its leadership play in maintaining ethical standards and regulatory compliance.

In contrast, the other options suggest narrower involvement, which does not align with regulatory expectations for collective IACUC responsibility. For example, the submission of the report only by the IACUC members who conducted the evaluation does not capture the perspectives of the entire committee, potentially undermining the thoroughness and objectivity required in such evaluations. Additionally, the submission to the Institutional Official (IO) rather than the CEO may neglect the broader oversight necessary