Under what circumstance would designated-member review result in a full committee review being called?

Designated-member review is a streamlined process that allows for certain protocols to be reviewed by a subset of an Institutional Animal Care and Use Committee (IACUC) members rather than the entire committee. However, one key aspect of this review process is that if any member of the designated reviewers has concerns or believes that the protocol merits a more thorough evaluation, they have the authority to call for a full committee review. This is crucial because it ensures that all voices and concerns are addressed, maintaining the integrity of the review process and ensuring that animal welfare and regulatory compliance are upheld.

Choosing to call for a full committee review emphasizes the collaborative nature of the IACUC and recognizes that even a single reviewer can signal that a more detailed discussion is needed. This safeguard within the process ensures that complex issues or ethical considerations are not overlooked, thus promoting thorough oversight in animal research.

The other circumstances provided, while they may seem relevant, do not serve as the primary triggers for calling a full committee review in the context of designated-member review.