What allows for the loss of AAALAC accreditation according to the provided context?

The loss of AAALAC accreditation is closely associated with various institutional practices, particularly concerning adherence to ethical standards and compliance with relevant regulations regarding animal care and use. Among the factors listed, institutional investigations play a crucial role in determining accreditation status.

When an institution is found to engage in practices that violate established guidelines or ethical standards, an investigation may be initiated. If the findings of such investigations highlight significant shortcomings or non-compliance in the institution's animal care practices, this can directly threaten its accreditation status with AAALAC. The organization prioritizes the welfare of animals and compliance with regulatory frameworks, and thus serious issues uncovered during institutional investigations can lead to losing accreditation.

In contrast, the introduction of new protocols or changes in management may not inherently result in loss of accreditation, as these actions can be routine and managed properly. Similarly, while failure to report adverse events is a critical issue, it may not always lead directly to loss of accreditation unless it is a continuation of a pattern of neglect or non-compliance identified in an investigation. Therefore, institutional investigations are often the first line of action that could trigger a thorough review of an institution's accreditation status.