What happens if a PI fails to complete the triennial review by the deadline?

If a Principal Investigator (PI) fails to complete the triennial review by the designated deadline, the result is that the protocol approval expires and must undergo a de novo review process. This requirement is part of ensuring that protocols remain in compliance with current standards, regulations, and ethical considerations regarding the care and use of animals in research.

The triennial review is an essential step allowing for the reevaluation of protocols at least every three years. It ensures that any past concerns or new regulations can be considered. If the PI does not complete this review on time, not only does it mean that the project cannot continue under the existing protocol, but it also necessitates a fresh evaluation where all aspects of the research proposal are reconsidered from the beginning. This process protects animal welfare and upholds the integrity of the research.

In contrast, the project continuing without issues, having the protocol automatically renewed, or only receiving a warning do not align with compliance requirements set forth by regulatory bodies overseeing animal research. These options would potentially undermine the seriousness of protocol review processes designed to safeguard ethical standards in research.