What is an indicator that a designated reviewer can begin their work?

The indicator that a designated reviewer can begin their work is when they receive the protocol after the waiting period ends. In the context of IACUC review processes, there are specific timelines and protocols that must be adhered to in order to ensure thorough and compliant evaluations. The waiting period allows for any necessary pre-review activities and ensures that members have had adequate time to consider the protocol before the designated reviewer begins their assessment.

This process is designed to uphold the integrity of the review and ensures that reviewers can make informed decisions based on a complete understanding of the submitted materials. The other choices focus on circumstances that do not directly trigger the start of the designated reviewer's work. For instance, member requests for a review before the deadline, or the need for all voting members to reply to the review request, do not establish conditions under which the designated reviewer can begin. Additionally, the requirement for a majority to agree unanimously to assign the review does not reflect the procedural step that allows a designated reviewer to initiate their work on the protocol.