What is the relationship between primary reviewers and designated reviewers in IACUC practice?

The relationship between primary reviewers and designated reviewers in IACUC practice is characterized by their distinct roles and responsibilities in the review process. Primary reviewers are typically individuals designated to conduct a thorough assessment of a specific animal use protocol, focusing on its scientific merit and ethical considerations. This role involves a comprehensive evaluation to ensure that the proposed study aligns with institutional policies and federal regulations.

In contrast, designated reviewers operate within a framework that allows them to conduct expedited reviews of protocols that meet criteria established for such reviews. Designated reviewers may have the authority to approve protocols without convening the full IACUC, but they still play a supportive role, often relying on the thorough evaluations conducted by primary reviewers when necessary.

Recognizing that primary and designated reviewers serve different functions within the IACUC process is essential for understanding how protocols are evaluated, approved, and monitored. This differentiation ensures that while expediency in the review process is maintained, the rigors of ethical oversight and scientific integrity are upheld.