What must the IO submit to the USDA/APHIS regarding major survival surgical procedures on regulated animals?

The correct response underscores the importance of obtaining prior approval for major survival surgical procedures on regulated animals. Under the Animal Welfare Act regulations as administered by the USDA/APHIS, any institution conducting major survival surgeries must seek approval from the Institutional Animal Care and Use Committee (IACUC) and ensure compliance with federal regulations. This approval process is crucial not only to safeguard the welfare of the animals involved but also to ensure that the procedures align with ethical standards and are scientifically justified.

Failure to obtain approval before performing such procedures could lead to serious ethical violations, non-compliance with federal regulations, and potential repercussions for the institution. The requirement emphasizes accountability and oversight in the use of animals in research and testing, thereby upholding the principles of humane animal care. Consequently, submitting a request for approval is the foundational step to obtain the necessary authorization to proceed, ensuring adherence to established guidelines and protocols.