What options do designated reviewers have during their review?

Designated reviewers play a crucial role in the Institutional Animal Care and Use Committee (IACUC) process by conducting reviews of proposed animal research studies. The correct answer highlights the range of options available to designated reviewers during their review process.

Designated reviewers are empowered to not only approve the proposal but also to require modifications if they identify aspects of the study that need refinement or additional details. This allows for a more nuanced approach to the review process, ensuring that studies adhere to ethical standards and regulatory requirements. Furthermore, if the designated reviewer believes that the proposal is complex or raises significant concerns, they also have the option to call for a full committee review. This ensures that all perspectives from the committee can be taken into account, particularly in instances where the welfare of animals is potentially at risk or where the research raises ethical questions.

In contrast to the other options, which either limit the reviewer's authority or do not accurately reflect the procedures of IACUC reviews, the correct answer encapsulates the full range of a designated reviewer’s responsibilities and the significant role they play in maintaining ethical standards in animal research.