What outcome option is available in full committee review but not designated review of animal protocols?

The outcome option that is available in full committee review but not designated review is the "withhold approval" option. During a full committee review, all members have the opportunity to thoroughly discuss the protocol and can decide not to grant approval if they have significant concerns about ethical issues, welfare of the animals, or compliance with regulations. This decision reflects the collective judgment of the full committee and can lead to withholding approval if the protocol does not meet the necessary standards.

In contrast, designated review is typically conducted by one or a few members of the IACUC who are empowered to approve protocols that do not raise significant issues. If they encounter concerns during a designated review, they do not have the authority to withhold approval outright; instead, they can require modifications before approval is granted. Therefore, this distinction highlights the broader authority of the full committee to take stronger action regarding the approval status of animal protocols.