What type of event must be reported as adverse regarding IACUC protocols?

The correct choice emphasizes the importance of transparency and regulatory compliance in animal research. Investigations by agencies such as the USDA (United States Department of Agriculture) or OLAW (Office of Laboratory Animal Welfare) must be reported as adverse events because they often signal potential violations of ethical standards or regulations governing animal welfare. Such investigations can have serious implications for the institution conducting the research, as they might relate to breaches of protocols that protect the humane treatment of animals in research settings.

These investigations are scrutinized closely and can result in further actions or changes to protocols if non-compliance is found. Reporting these events ensures that the IACUC is aware of potential risks, helps in maintaining compliance with federal regulations, and supports the institution’s commitment to animal welfare and research integrity.

By highlighting the necessity of reporting such investigations, the correct option underlines the greater responsibility of research institutions to adhere to ethical expectations and to continually strive for improvement in their animal care practices.