Which official must approve changes to the animal care program?

The Institutional Official plays a crucial role in the oversight of the animal care and use program within institutions that engage in research involving animals. This position is typically responsible for ensuring that the institution complies with federal, state, and local laws and regulations governing animal research, as well as institutional policies.

The approval for changes to the animal care program falls under the purview of the Institutional Official because they have the authority and responsibility to ensure that the animal care program operates within the ethical and regulatory framework required by the Institutional Animal Care and Use Committee (IACUC). This individual is integral in maintaining the integrity of the program and ensures that any modifications align with the institution's commitment to the humane treatment of animals and adherence to research standards.

Other roles, such as the Chief Financial Officer, Chief Executive Officer, or Chief Operations Officer, may participate in the operational aspects of the institution, but they do not typically have direct oversight of the animal care program or the authority to approve changes. Their involvement may be indirect, primarily revolving around ensuring that resources are allocated appropriately, but the ultimate responsibility for approving changes specifically rests with the Institutional Official.