Which outcomes are recognized in IACUC protocol reviews according to regulations?

The recognized outcomes in IACUC protocol reviews according to regulations include the need to either approve or modify protocols before they can proceed, and in some instances, withholding approval altogether if the protocol does not meet regulatory standards. The outcome "approve" indicates that the protocol meets all regulatory requirements and can move forward. "Require modifications" means the committee identifies certain aspects of the protocol that need improvement or clarification to ensure compliance with ethical standards and regulations. "Withhold approval" is a necessary outcome when a protocol has significant concerns or does not align with the regulatory requirements or ethical considerations, preventing it from being initiated until those issues are adequately addressed.

This understanding aligns well with the IACUC's responsibilities in ensuring that animal welfare is prioritized while balancing the need for scientific research, which is essential in the decision-making process during protocol reviews.