Which situation requires the full IACUC committee's review rather than Designated Member Review?

The situation involving major changes in the research protocol necessitates the full IACUC committee's review because such changes can significantly impact the welfare of the animals involved, the scientific validity of the study, and compliance with regulations. Major modifications might alter the scope of the project, introduce new risks, or require new procedures that could affect animal housing, care, or use. This level of impact warrants comprehensive evaluation and discussion among the entire committee to ensure that all potential consequences are thoroughly assessed and appropriate measures are in place to safeguard the animals and maintain ethical standards.

In contrast, minor adjustments to animal housing conditions, clarifications of animal welfare assurances, and routine updates on training programs typically can be handled through Designated Member Review, which allows for a more efficient process for less significant changes that are unlikely to pose substantial risk to animal welfare or alter the fundamental aspects of the research. The full committee's oversight is essential for significant alterations to ensure a thorough understanding of the implications and to uphold the ethical responsibilities of the institution.