Which statement regarding modifications to animal protocols after IACUC approval is TRUE?

Significant changes to animal protocols after IACUC approval must indeed be reviewed and approved by the IACUC before they are implemented. This requirement is rooted in the principles of ethical research and compliance with regulations to ensure the welfare of animals involved in research. The IACUC is responsible for overseeing all animal use in research settings, and any modifications that could impact animal care, welfare, or the objectives of the study must be closely examined to maintain compliance with federal regulations, ethical standards, and institutional policies.

When significant changes occur, such as alterations in the experimental design, objectives, or methods that could affect animal well-being or the scientific validity of the study, they require careful scrutiny by the IACUC. This process ensures that all potential implications are considered, and that the animal's welfare remains a priority in research activities. This careful oversight aligns with the overarching goal of ensuring humane and ethical treatment of research animals.