Who has the authority to approve amendments to protocols involving specific animal types in DoD research?

In Department of Defense (DoD) research, the authority to approve amendments to protocols involving specific animal types rests with the Component headquarters. This oversight is essential for ensuring that all research involving animal subjects adheres to federal regulations and ethical standards set forth by organizations such as the IACUC (Institutional Animal Care and Use Committee).

The Component headquarters play a critical role in maintaining the integrity and compliance of research practices, particularly because they establish policies that govern the use of animals in research. They ensure that any changes to protocols align with mission objectives and compliance requirements.

Other entities, such as principal investigators or the IACUC chairperson, may have roles in proposing or reviewing amendments, but the final approval typically requires the oversight and authority vested in the Component headquarters. This structure reflects the hierarchical nature of management within the DoD and the emphasis on accountability in research involving animal welfare.